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Clinical Resources

& Evidence

1. Purification of Human Immunoglobulin G with Bathophenanthroline–Zn²⁺, –Fe²⁺, or –Cu²⁺ Complexes. 
Thisara Jayawickrama Withanage, Ron Alcalay, Olga Krichevsky, Ellen Wachtel, Ohad Mazor, Guy Patchornik. 
Antibodies (2025) 14(2), 40. https://doi.org/10.3390/antib14020040 

2. Purification of a Fc-Fusion Protein with [Bathophenanthroline:Metal] Complexes
Thisara Jayawickrama Withanage, Ron Alcalay, Olga Krichevsky, Ellen Wachtel, Ohad Mazor, Guy Patchornik.
Antibodies (2025) 14(1), 11
https://doi.org/10.3390/antib14010011

3. The [(Bathophenanthroline)₃:Fe²⁺] Complex as an Aromatic Non-Polymeric Medium for Purification of Human Lactoferrin
Thisara Jayawickrama Withanage, Mitra Lal, Hagit Salem, Olga Krichevsky, Ellen Wachtel, Guy Patchornik.
Journal of Chromatography A (2024) 1732, 465218
https://doi.org/10.1016/j.chroma.2024.465218

4. Conjugated Nonionic Detergent Micelles: An Efficient Purification Platform for Dimeric Human Immunoglobulin A
Thisara Jayawickrama Withanage, Mitra Lal, Ellen Wachtel, Guy Patchornik.
ACS Medicinal Chemistry Letters (2024) 15(6), 979–986
https://doi.org/10.1021/acsmedchemlett.4c00128

5. Efficient Separation of IgG from IgM Antibodies via Conjugated Surfactant Micelles
Thisara Jayawickrama Withanage, Rami Krieger, Ellen Wachtel, Guy Patchornik.
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences (2023) 1226, 123805
https://doi.org/10.1016/j.jchromb.2023.123805

6. Conjugated Surfactant Micelles: A Non-Denaturing Purification Platform for Concentrated Human Immunoglobulin G
Gunasekaran Dhandapani, Ellen Wachtel, Guy Patchornik.
Nano Select (2023) 4(6), 386–394
https://doi.org/10.1002/nano.202200251

7. Conjugated Detergent Micelles as a Platform for IgM Purification
Gunasekaran Dhandapani, Ellen Wachtel, Ishita Das, Mordechai Sheves, Guy Patchornik.
Biotechnology and Bioengineering (2022) 119(7), 1997–2003
https://doi.org/10.1002/bit.28089

8. Detergent Micelle Conjugates Containing Amino Acid Monomers Allow Purification of Human IgG Near Neutral pH
Gunasekaran Dhandapani, Ellen Wachtel, Guy Patchornik.
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences (2022) 1206, 123358
https://doi.org/10.1016/j.jchromb.2022.123358

9. Purification of Antibody Fragments via Interaction with Detergent Micellar Aggregates
Gunasekaran Dhandapani, Ellen Wachtel, Ishita Das, Mordechai Sheves, Guy Patchornik.
Scientific Reports (2021) 11(1), 11697
https://doi.org/10.1038/s41598-021-90966-1

10. Nonionic Detergent Micelle Aggregates: An Economical Alternative to Protein A Chromatography
Gunasekaran Dhandapani, Ellen Wachtel, Mordechai Sheves, Guy Patchornik.
New Biotechnology (2021) 61, 90–98
https://doi.org/10.1016/j.nbt.2020.11.013

11. A General Platform for Antibody Purification Utilizing Engineered Micelles
Gunasekaran Dhandapani, Assaf Howard, Thien Van Truong, Thekke V. Baiju, Ellina Kesselman, Noga Friedman, Ellen Wachtel, Mordechai Sheves, Dganit Danino, Irishi N. N. Namboothiri, Guy Patchornik.
mAbs (2019) 11(3), 583–592
https://doi.org/10.1080/19420862.2019.1565749

12. Role of Amphiphilic [Metal:Chelator] Complexes in a Non-Chromatographic Antibody Purification Platform
Gunasekaran Dhandapani, Dileep K. Nair, Raju R. Kale, Ellen Wachtel, Irishi N. N. Namboothiri, Guy Patchornik.
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences (2019) 1133, 121830
https://doi.org/10.1016/j.jchromb.2019.121830
 

Explore peer-reviewed publications supporting the development of AromAb's APPC™ platform and alternative approaches to antibody and protein purification.

Clinical Publications

AromAb
Leiden, The Netherlands

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